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Can Wasabi-Derived Hexaraphane Regenerate Dentin in Sensitive Teeth? A Novel TRPA1-Independent Mechanism
Hexaraphane
9 min read
Can Wasabi-Derived Hexaraphane Regenerate Dentin in Sensitive Teeth? A Novel TRPA1-Independent Mechanism
An explanation of a 2026 study in The Journal of Physiology showing that Japanese wasabi–derived hexaraphane (6-MSITC) promotes mineralization in odontoblasts and supports the formation of reactionary dentin through a TRPA1-independent, coordinated ion-transport pathway (the CA–SLC4As–NHE–NCX–PMCA axis).
Japanese Wasabi and Horseradish: What Is the Difference, and Where Does Hexaraphane Come From?
Hexaraphane
9 min read
Japanese Wasabi and Horseradish: What Is the Difference, and Where Does Hexaraphane Come From?
This article outlines the differences between Japanese wasabi and horseradish, explains that hexaraphane is abundant in the rhizome of Japanese wasabi, and discusses why ordinary shelf-stable tube wasabi is unlikely to serve as a source of this compound.
Aging Research in 2026: How Far Has the Science of Slowing Aging Come?
13 min read
Aging Research in 2026: How Far Has the Science of Slowing Aging Come?
An overview of recent aging research from the perspectives of interconnected bodily mechanisms, cellular resilience, lifestyle, and individual differences—explaining where the field stands and how to interpret it.